Promoters selected from random DNA sequences.
نویسندگان
چکیده
منابع مشابه
Clustering of DNA sequences in human promoters.
We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative transcription start site (TSS). A limited number of 8-mers have peaks in their distribution (cluster), and most cluster within 100 bp of the TSS. The 156 DNA sequences exhibiting the greatest statistically ...
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In this paper, the notion of "regularity" is introduced to describe the structural features of DNA sequences. This notion expands the "latent periodicity" term. The novel method for revealing regularity based on the runs test is described. The search of regular sequences in eukaryotic promoters has shown that more than 60% of them possess a regularity property on statistically significant level...
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Genomewide techniques to assay gene expression and transcription factor binding are in widespread use, but are far from providing predictive rules for the function of regulatory DNA. To investigate more intensively the grammar rules for active regulatory sequence, we made libraries from random ligations of a very restricted set of sequences. Working with the yeast Saccharomyces cerevisiae, we d...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.19.7405